Bronchial asthma (AD) is a chronic inflammatory disease of the respiratory system, characterized by bronchial hyperreactivity, partially or completely reversible (spontaneously or due to treatment) bronchial obstruction resulting from bronchospasm, as well as mucus hypersecretion and swelling of the bronchial mucosa. AD is clinically manifested by wheezing in the lungs, coughing, shortness of breath, and signs...
Atropine is a natural compound proposed for asthma, but given its side effects (especially inhibition of secretion), less soluble quaternary compounds (e.g. ipratropium bromide) have been developed. Anticholinergic drugs are specific antagonists of muscarinic receptors and inhibit bronchoconstriction induced by stimulation of cholinergic nerves. There is a slight decrease in bronchial tone due to tonic...
The name asthma denotes a breathing difficulty of a special kind that occurs in the form of attacks, as a result of allergic reactions in the bronchial tree. Bronchial asthma is a manifestation of hypersensitive reactions of the respiratory tract to irritants that have penetrated into the lungs by air or blood, or both. The...
Immunological hypersensitivity is an overreaction of the immune system to a specific substance and is probably the form of immunotoxicity most commonly observed in patients. This reaction essentially means lowering the threshold of clinical sensitivity to an antigenic stimulus. When describing hypersensitivity, terms such as anaphylaxis, atopy and allergy are used. a) Contact sensitivity and skin disorders . Occupational...
Occupational asthma has become the most common pulmonary disease in developed countries. About 250 substances can cause occupational asthma. Isocyanates are the cause of the most common form of this disease. The incidence of isocyanate-induced asthma among workers exposed to this substance is close to 10%. The mechanisms of pathological lesions in occupational lung diseases are listed in the table...
Asthmatics undergo deep morphological changes in the bronchi – remodeling (increase in smooth muscle mass and secretion of viscous sputum, thickening of BM, bronchospasm), which largely determines the severity of bronchial asthma. So, in the case of death of a patient from asthmatic status (AS), five characteristic structural changes are found that are unevenly distributed...
The intensity of treatment corresponds to the severity of the attack (Fig. 4-9). Mild exacerbations of asthma are treated at home by temporarily increasing the frequency of use of short-acting bronchodilators with or without a course of oral steroids. In this case, a plan of action for asthma helps, and therefore there is no need to involve...
Mild or moderate severity of persistent bronchial asthma should be treated with long-acting supportive agents, which include NSAIDs, inhaled glucocorticoids, theophylline depot preparations, long-acting b2-adrenostimulants and leukotriene modulators. NSAIDs for bronchial asthma in children Cromoline and nedocromil inhibit the manifestations of the early and late phases of an allergic asthmatic reaction and can relieve bronchospasm caused by physical effort. Both...
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