In the pathogenetic mechanism of allergic asthma, histamine is an independent, as it were, decisive factor involved in the occurrence of an allergic (asthmatic) phenomenon. He takes part in causing pathological bronchiospasm and increased mucus secretion in asthma. It is necessary to take into account the fact that histamine is formed physiologically for physiological processes in the body. In an allergic body, histamine is contained in an abnormally large amount. It is released under the influence of a meeting of an antigen with an antibody, but also during temperature fluctuations and other physical influences, during infections, and when certain substances are introduced into the body. Physiologically free histamine is consumed in biological reactions. Its pathogenic effect is manifested when, during normal formation, insufficient enzymatic cleavage occurs, or in cases when it does not bind to inactive forms, in violation of plasma histamine kinemia (fixation of healthy people on gammaglobulin), or when these processes are insufficient with its excessive education. In an allergic organism, even an antipectic substance is formed, antipexin, which prevents the capture of histamine from plasma. The histaminopectic property is absent not only in the plasma of allergic children, but also in the plasma of their parents, some relatives and, finally, non-allergic parents who have allergic ancestors (Laborde 1953, 1959, Parrot 1953, 1956, 1958). Here, perhaps, mention should be made of the Bowen’oM (1953) study of 59 identical twins. Out of 52 allergies were identified in only one of the twins, and only in seven cases in both twins. In most individuals who are allergic-prone to form antibodies against external allergens, this ability is activated in childhood or until adulthood, less often later. In a suitable situation, with a suitable antibody arrangement (Sonak 1960), allergens cause, for example, an asthma attack or some other allergic reaction. Eczema may be a precursor to bronchial asthma. It is worth mentioning that antihistamines used to inhibit allergic processes can sensitize the body, and subsequent intake can trigger an asthma attack. To overcome many ambiguities, it is assumed that various antibodies are unevenly distributed in all cells of the body. Their presence is supposed or proved mainly in the tissues of the upper and lower parts of the respiratory tract, in the skin and in some tissues of the gastrointestinal organs. But even in these tissues of the same face they are not contained to the same degree, uniformly and of the same quality. If antibodies are contained in the tissues of the gastrointestinal tract, convulsions in the intestine may occur, accompanied by or without mucous colopathy, sometimes other disorders. Antibodies can be contained in the skin, and then urticaria occurs. They can be found in the nasal mucosa and conjunctiva, causing vasomotor rhinitis and conjunctivitis. If antibodies are contained in the mucous membrane of the bronchial tree, then inhalation of the corresponding allergen or its delivery through the bloodstream causes bronchial disorders and paroxymal asthma. Protective and cleansing effects are attributed to locally detained and activated eosinophils. There is evidence that eosinophils are carriers of proteolytic enzymes, especially effective in certain allergic situations and perform an important cleansing function. Their presence in uninfected bronchial mucus is considered evidence of an allergic condition in these areas.